Increasing the amount of Aβ produced by 50% or specifically increasing the more fibrillogenic Aβ 42 either by APP gene dose or mutations in amyloid precursor protein ( APP), PS1, or PS2, accelerates the onset of Aβ deposition and AD ( 3). A number of studies demonstrate that aggregation of Aβ is concentration-dependent ( 2). Evidence indicates that the aggregation and accumulation of the amyloid-β (Aβ) peptide in the brain extracellular space is a key initiating event in the pathogenesis of Alzheimer's disease (AD) ( 1).
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Steinmetz suffered from dwarfism, hunchback, and hip dysplasia, as did his father and grandfather. Religion his family "nominally" belonged to. Steinmetz was born Karl August Rudolph Steinmetz on Apin Breslau, Province of Silesia, the son of Caroline (Neubert) and Karl Heinrich Steinmetz. That enabled engineers to design better electromagnetic apparatus equipment including especially electric motors for use in industry. He made ground-breaking discoveries in the understanding of hysteresis Possible the expansion of the electric power industry in the United States, formulating mathematical theories for engineers. He fostered the development of alternating current that made
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